Two Words: Mobile and Responsive
Great read about where web design is headed in 2012 over at .Net Magazine. The big ones to focus on here are mobile and responsive though.
Mobile is obvious as more people use their phones to find your business online you need to make sure your website presents itself appropriately. Which ties in with Responsive perfectly.
Don’t think you can make two websites: one for desktop and one for mobile, because you then need to make one for the iPad and now the iPad retina display. Don’t forget about the 14 different mobile phone screen sizes out there and more to come. Instead build one website that responds to the device viewing it so that the text is readable regardless.